Difference between revisions of "Some studies using animal models"
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Revision as of 05:11, 29 July 2012
- "Other fields in psychiatry, most notably in the realms of addiction and anxiety, have prospered from results obtained in parallel studies using animalmodels and experimental human studies. Lessons to be learned from those models and recent genetic and cognitive insights in schizophrenia can be utilized to develop better animal and human models and, potentially, novel treatment strategies."
- "The new, third generation AEDs, which have been discovered by testing of large numbers of investigational compounds in animalmodels over the last 20 years, have undoubtedly expanded the therapeutic options, in particular for those in need for a change in medical regimen"
- "While no single animalmodel is entirely successful in reproducing the complete spectrum of pathological changes observed after injury, the validity of these animalmodels including face, construct, etiological and construct validity and how the models constitute theories about brain injury is addressed."
- "These studies have revealed fundamental roles for these protein kinases in memory, behavior, and neuronal fate determination and provide insights into possible therapeutic interventions."
- "Although no animal model captures human disease precisely, behaviours that recapitulate disease symptoms may be elicited and modulated by optogenetic methods, including behaviours that are relevant to anxiety, fear, depression, addiction, autism and parkinsonism."
- "Breakthroughs in the last two decades using animal models have offered insights into the understanding of the PD (Parkinson Disease) disease process, its etiology, pathology, and molecular mechanisms. Furthermore, while cellular models have helped to identify specific events, animal models, both toxic and genetic, have replicated almost all of the hallmarks of PD and are useful for testing new neuroprotective or neurorestorative strategies."